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The drug delivery system(DDS) are the carrier system which focuses on delivery of therapeutic drug or bioactive agent to reach effectively to the desired site of action. DDS in the field of dentistry are used to treat oral infections, periodontal diseases, TMJ disorders and other conditions. Local drug delivery system (LDDs) is suitable to treat periodontitis since systemic administration is usually related to gastrointestinal issues,the need for frequent doses to maintain high blood concentration of the drug, and other collateral effects, such as dysbacteriosis or drug resistance. Various LDDs are used as adjunct to SRP in treating periodontitis as they provide sufficient time lapse at a high enough concentration.Statins are one of the most commonly prescribed drugs to control the serum cholesterol levels and reduces the risk of cardiovascular disease. Apart from cardio protective benefits, statins have been ascribed for showing various additional pleiotropic effects like antioxidant, antimicrobial, immune-modulatory and anti-carcinogenic properties. Among various statins, simvastatin (SMV) has gained importance in the field of periodontal therapy. The anti-inflammatory action of 1.2% simvastatin as a LDD have showed a significant improvement in the clinical indicators of periodontal disease. One of the key sources of reactive oxygen species (ROS) in periodontal tissues is Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase, the anti-oxidative action of SMV is inhibition of activity of NADPH oxidase and downregulation of angiotensin 1 receptor expression.Few studies also suggest that, simvastatin possessed anti-oxidative properties through several different mechanisms. On the one hand, simvastatin acts an active scavenger by inhibition of NADPH oxidase which is one of the most important sources of ROS preventing lipid peroxidation & protein oxidation. On the other hand, simvastatin helps in upregulation of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase etc.
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Date: 01/12/2024| 02:00 PM IST
